Levobunolol (HCl)

Levobunolol (HCl) is a non selective, β adrenergic blocking agent. Levobunolol (HCl) is synthesized chemically and optically active. The (S) enantiomer (levorotatary isomer) is used clinically, as Levobunolol (HCl) is 60 times more potent than the (R) enantiomerin in β blocking activity. It reducesintra-ocular pressure (IOP) and used to treat glaucoma or other eye conditions. Levobunolol (HCl) is available for both opthalmic and oral use.

Brands
BETAGAN LEVOLOL VOBEN VISTAGAN LEVOSAN ORBUNOL OCUGAN OPHTH-LEVO LEVOPTIC
Adult Dose
Dose: 0.25 mg
Single Dose: 0.25 (0.25)
Frequency: 12 hourly
Route: Ophthalmic
Instructions: -
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Tetrahydronaphthalen. It belongs to Opthalmic Products and Antiglaucoma pharmacological group.The Molecular Weight of Levobunolol (HCl) is 327.90. Its pKa is 9.4.
Contraindications
Levobunolol (HCl) is contraindicated in conditions like Myasthenia gravis,Thyrotoxicosis,Cardiogenic shock,Sinus bradycardia,General anaesthesia,Second or third degree A-V block,Bronchial asthma.
Effects
The severe or irreversible adverse effects of Levobunolol (HCl), which give rise to further complications include Bronchospasm, Bronchospasm, Sinus bradycardia, Ocular irritation.The symptomatic adverse reactions produced by Levobunolol (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Ataxia, Diarrhea, Urticaria, Pruritus, Bradycardia, Lethargy, Depression, Heart burn, Fall in BP, Stinging on application, Respiratory difficulty, dizziness, Ataxia, Heart block.
Indications
Levobunolol (HCl) is primarily indicated in conditions like Ocular hypertension, Open-angle glaucoma, and can also be given in adjunctive therapy as an alternative drug of choice in Depression, Myocardial infarction.
Interactions
Levobunolol (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineAmiodarone (HCl)Increased risk of bradycardia, AV block, myocardial depression and ventricular arrhythmias when amiodarone is given with beta-blocker (e.g Levobunolol).Clonidine (HCl)DigoxinQuinidineTheophylline These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Cardiac / Hypertensive Patients, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Eye Drops Store Below 40°C. Protect from Sunlight.
Warnings
Levobunolol should be used only if clearly needed during pregnancy or lactation.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.