Letrozole

Letrozole is a new oral nonsteroidal inhibitor of aromatase activity. Letrozole is used to treat advanced breast cancer in women in whom tamoxifen is failed.


Adult Dose
Dose: 2.5 mg
Single Dose: 2.5 (2.5)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Dose: Not applicable in this age group
Single Dose:
Frequency:
Route:
Instructions:
Paedriatic
Dose: Not applicable for this age group
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
belongs to Benzonitrile. It belongs to Antineoplastic Agent, Aromatase Inhibitor pharmacological group.The Molecular Weight of Letrozole is 285.30.
Contraindications
Letrozole
Effects
The severe or irreversible adverse effects of Letrozole, which give rise to further complications include Thromboembolic disorder.The symptomatic adverse reactions produced by Letrozole are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Diarrhea, Myalgia, Dyspnea, Abdominal pain, Rashes, Coughing, Nausea and vomiting, Hot flushes, SomnolenceX, Vaginal dryness, Stevens Johnson syndrome, dizziness, Bone fracture.
Indications
Letrozole is primarily indicated in conditions like Breast cancer, and can also be given in adjunctive therapy as an alternative drug of choice in Advanced breast cancer in postmenopausal women.
Interactions
No data regarding the interactions of Letrozole was found.
Interfrence
Elevations of SGPT and SGOT Increases Serum Bilirubin
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Letrozole should be used with caution in patients with any allergies (especially drug allergies) or liver disease. Limit alcohol intake as it may increase the side effects of this drug. It should be used with caution while performing tasks requiring mental alertness (e.g.driving), because this drug may cause drowsiness. It is not recommended for use during pregnancy.
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