Lansoprazole

Lansoprazole is an acid proton pump inhibitor. Lansoprazole is a benzimidazole sulfoxide derivarive and produces long lasting inhibition of gastric acid secretion. Lansoprazole is a chiral cmpound with one chiral center, synthsized as a racemic mixture and both enantiomers are active. Chemically Lansoprazole is identified as 2-[[[3-methyl-4-(2, 2, 2-trifluoroethoxy)-2-pyridinyl] methyl] sulfinyl ]-1H-benzimidazole. Lansoprazole is effective in the treatment of duodenal or gastric ulcer, gastroesophageal reflux disease and in the treatment of zollinger-ellison syndrome. Lansoprazole is administered orally.


Adult Dose
Dose: 15 to 30 mg
Single Dose: 22 (22.5)
Frequency: 24 hourly
Route: PO
Instructions: Frequency may increased to twice.15 mg/day is given on an empty stomach.
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose: 15 mg
Single Dose: 15 (15)
Frequency: 24 hourly
Route: 30 mg or less.
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Sulphinyl Benzimidazole. It belongs to H/K Atpase proton pump inhibitor pharmacological group on the basis of mechanism of action and also classified in Antacids pharmacological group.The Molecular Weight of Lansoprazole is 369.00. Its pKa is 8.85.
Contraindications
Lansoprazole is contraindicated in conditions like Liver diseases.
Effects
The severe or irreversible adverse effects of Lansoprazole, which give rise to further complications include Epidermal necrolysis, Atrophic gastritis.The symptomatic adverse reactions produced by Lansoprazole are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Diarrhea, Constipation, Rashes, Pruritus.
Indications
Lansoprazole is primarily indicated in conditions like Acid-related dyspepsia, Benign gastric ulcer, Duodenal ulcer, Duodenal ulcer associated with h. Pylori, Esophagitis, Gastric ulcer, Gastro-oesophageal reflux disease, Heart burn, Helico-bacter pylori positive duodenal ulcer, NSAID-associated gastric and duodenal ulcers, NSAID-associated gastric and duodenal ulcers (prophylaxis), NSAID-associated gastric or duodenal ulcers, Peptic ulcer, Resistant ulcers, Zollinger-ellison syndrome, and can also be given in adjunctive therapy as an alternative drug of choice in GI bleeding.
Interactions
Lansoprazole is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCeftibutenCilostazoleOmeprazolePhenytoin (Na)Sodium DiatrizoateShould not be use concurrently without informing doctor.SucralfateTheophyllineWarfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Elevations of SGPT and SGOT Abnormal LFTs Increased Alkaline Phosphatase LevelsElevation in ALT or ASTIncreased in serum creatinin
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store Below 40°C. Protect from Sunlight and Heat.
Warnings
Lansoprazole should be used with caution in patients with any pre-existing liver disease or in case of any allergy. It should be used only if clearly needed during pregnancy or lactation. Since gastric acid secretion and other phsiological functions are decreased in elderly patients lansoprazole should be administered with caution.
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