Lamotrigine is a triazine derivarive and chemically Lamotrigine is idetified as 6-(2, 3-dichlorophenyl)-1, 2, 4-triazine-3, 5-diamine, prepared by chemical synthesis. Lamotrigine is oral antiepileptic and anticonvulsant agent developed based on the observation that some antiepileptic drugs possess antifolate activity. Although derived from agents which inhibit dihydrofolate reductase, it has relatively little antifolate activity. It blocks voltage dependent sodium channels. The exact mechanism by which it exhibits its anticonvulsant activity is not known, but studies suggest that it may stabilize neuronal membranes by acting at voltage-sensitive sodium channels. Blocking sodium channels can decrease the presynaptic release of glutamate, an excitatory amino acid, and aspartate resulting in decreased seizure frequency.it can be used alone or as a second-line, additional treatment in patients not staisfactorily controlled on other anticonvulsants.it was originally approved by the FDA December 28, 1994.
Effects
The severe or irreversible adverse effects of Lamotrigine, which give rise to further complications include Ataxia, Thrombocytopenia, Aplastic anemia, Aplastic anemia, Stevens johnson syndrome, Epidermal necrolysis, Lymphadenopathy, Lymphadenopathy, Stevens johnson syndrome, Angioedema, Leucopenia, Neutropenia, Nystagmus, Extrapyramidal symptoms, Angioedema, Pancytopenia, Tremors, Epidermal necrolysis, Hepatic failure, Aplastic anemia, Facial edema, Choreoathetosis.The symptomatic adverse reactions produced by Lamotrigine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Irritability, Ataxia, Nausea, Fever, Anxiety, Insomnia, Blurred vision, Maculopapular rash, Rashes, Confusion, Sedation, Malaise, Depression, Tremor, Diplopia, Arthralgia, SomnolenceX, Agitation, Anemia, Liver dysfunction, Aggression, Confusion, dizziness, Ataxia.