Calcifediol

'Calcifediol is a vitamin D3, a fat soluble sterol, sometimes considered to be hormone or hormone precursor. Calcifediol is involved in promoting normal bone development in body by regulating calcium, phosphorus and minerals. Vitamin D is a secosteroid and sometimes popularly known as the ''sunshine vitamin'' because formed in the skin from 7-dehydrocholesterol under the influence of ultraviolet irradiation. Calcifediol is also found in certain foods. Fish liver oils especially code liver oil are good sources of vitamin D.Calcifediol is used topically as a teratment of psoriasis'


Adult Dose
Dose: 100 to 200 mcg
Single Dose: 150 (150)
Frequency: 24 hourly
Route: PO
Instructions: Every alternate day.
Neonatal
Dose: 0.05 to 0.1 ug/kg
Single Dose: 0.075 (0.075)
Frequency: As recommended.
Route: Oral
Instructions: Single dose
Paedriatic
Dose: 0.05 ug/kg
Single Dose: 0.05 (0.05)
Frequency: As recommended.
Route: Oral
Instructions: Single dose
Characteristics
Calcifediol also known as 25-OH Vitamin D3. . It is of Synthetic origin and belongs to Secochloesta. It belongs to Vitamin D agonist pharmacological group on the basis of mechanism of action. The Molecular Weight of Calcifediol is 400.60.
Contraindications
Calcifediol is contraindicated in conditions like Hypercalcaemia,Granulomatous disease.
Effects
The severe or irreversible adverse effects of Calcifediol, which give rise to further complications include Urinary stone formation.Calcifediol produces potentially life-threatening effects which include Hypercalcemia, Hyperphosphatemia, Hypermagnesemia, Calcification in arteries & soft tissues. which are responsible for the discontinuation of Calcifediol therapy.The signs and symptoms that are produced after the acute overdosage of Calcifediol include Hypercalcemia.The symptomatic adverse reactions produced by Calcifediol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Thirst, Headache, Nausea, Vomiting, Anorexia, Abdominal pain, Apathy, Somnoparalytic ileus, Cardiac arrhythmias, Polyuria, Dehydration.
Indications
Calcifediol is primarily indicated in conditions like Cholestasis, Hyperparathyroidism, Hypoparathyroidism, Malabsorption, Nephrotic syndrome, Nutritional osteomalacia, Renal failure, Short bowel syndrome, Vitamin D deficiency rickets, Vitamin D-resistant rickets.
Interactions
No data regarding the interactions of Calcifediol was found.
Interfrence
Risks
Drug should not be given to patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, Below 40°C. Protect from Sunlight.
Warnings
Evaluate Vitamin D administration in fortified food, diet and drugs. It may be necessary to limit dietary Vit.D during treatment. If products of Vitamin D contain tartrazine may cause allergic reaction (including bronchial asthma) in susceptible individuals, especially patients with aspirin hypersensitivity.
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