KETRODIL KETRODIL TORALAC TORADOL TORADOL TORADOL TORADOL TORADOL KETROSAN TROMIT K-DOL TORAPAN MONAK MONAK KETRO DYLAC TOROLAC TOROLAC KETOMED TROMETH TROMETH STROLAC KETILAC KETOLAC TORAPAN KELAC KELAC KETOPAN KETOPAN

Dose: 15 to 30 mg
Single Dose: 22 (22.5)
Frequency: 6 hourly
Route: IM
Instructions: For 5-Days

Dose: 1 mg/kg
Single Dose: 1 (1)
Frequency: As recommended.
Route: 2 to 16 years, To maximum of 30 mg.
Instructions:

Ketorolac (Tromethamine) also known as Ketorolac Trometamol. . It is of Synthetic origin and belongs to Pyrolizine carboxy carboxylic acid. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Ketorolac (Tromethamine) is 376.40. Its pKa is 3.54.

Ketorolac (Tromethamine) is contraindicated in conditions like Asthma,Hypertension,Hypovolaemia,Peptic ulcer,Rhinitis,Renal artery stenosis,Hypersensitivity,Dehydration,Hepatic cirrhosis with ascites,Coagulation disorder,Cerebrovascular hemorrhage.

The severe or irreversible adverse effects of Ketorolac (Tromethamine), which give rise to further complications include Convulsions, Peptic ulceration, Peptic perforation, Renal impairment, Autoimmune hemolytic anemia.Ketorolac (Tromethamine) produces potentially life-threatening effects which include GI bleeding, Hypotension, Bronchospasm, Bronchospasm, Anaphylaxis, Laryngeal edema. which are responsible for the discontinuation of Ketorolac (Tromethamine) therapy.The signs and symptoms that are produced after the acute overdosage of Ketorolac (Tromethamine) include Hypotension, Nausea, Convulsions, Coma, Blurred vision, Drowsiness, Headache, Epigastric pain, GI bleeding.The symptomatic adverse reactions produced by Ketorolac (Tromethamine) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Diarrhea, Palpitation, Insomnia, Abdominal pain, Sweating, Dry mouth, Dyspepsia, Somnolence, Hypersensitivity, Rectal bleeding, Fluid retention, Chest pain, Asthma, Paresthesias, Pain at injection site, Dry mouth, Pain at injection site, dizziness, dyspepsia.

Ketorolac (Tromethamine) is primarily indicated in conditions like Maintenance in schizophrenia and other psychoses, Moderate to severe pain, Ocular inflammation, Resistant schizophrenia, and can also be given in adjunctive therapy as an alternative drug of choice in Allergic conjunctivitis, Migraine, Short term managment of moderate to severe acute post-operative pain.

Ketorolac (Tromethamine) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAspirinConcurrent use of ketorolac and aspirin increases the risk of aspirin adverse effects.MajorCoadministration of these agents is considered contraindicated.Heparin (Na) and Heparin (Cl)LithiumMethotrexateKetorolac reduces the renal elimination of methotrexate result in increased toxicity and pharmacological effect.MajorClosely monitor for sign and symptoms of bone marrow suppression and nephrotoxicity.MorphinePentoxifyllineProbenecidTinzaparin SodiumConcurrent use may increase the risk of bleeding.If coadministration is essential, close clinical and laboratory monitoring of these patients is advised.Warfarin (Na)Increased risk of haemorrhage with ketorolac.AVOID CONCOMITANT USE. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Abnormal LFTs Complete blood cell count

Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab, Inj Store Between 15°C-30°C. Protect from Sunlight and Moisture.

Ketorolac Tromethamine should be used with caution in patients with history of hypersensitivity to aspirin or other NSAIDs, asthma, bronchospasm, pre-existing coagulopathy, angioedema, peptic ulcer, gastrointestinal bleeding, renal impairment, heart failure, liver disease. The dose should be reduced in elderly or in patients weighing less than 50 kg. All the patients receiving prolonged treatment should be routinely monitored for potential GI ulceration and bleeding. It is not recommended during pregnancy or lactation. IM injection should not be administered to the patient receiving Ketorolac Tromethamine.