Immune Globulin

'Immune Globulin is a concentrate of antibodies of human plasma. Immune Globulin is used to increase the immunity to some viral infections (like hepatitis, measles and rubella) and increases the body''s natural immune response in persons with a compromised immune system and Immune Globulin is also used to increase blood count in persons with idiopathic thrombocytopenic purpura (decrease counts of platelets). Immune Globulin are produced by B lymphocytes in response to foriegn antigens.'


Adult Dose
Dose: 200 to 400 mg/kg
Single Dose: 300 (300)
Frequency: As recommended.
Route: IV
Instructions: Once in a Month or As Required
Neonatal
Dose: 4 mg/kg
Single Dose: 4 (4)
Frequency: 24 hourly
Route: Intravenous
Instructions: For 2---5 days
Paedriatic
Dose: 100 to 200 mg
Single Dose: 150 (150)
Frequency: As recommended.
Route: IM
Instructions: Once in a Month or As Required. Under 1 year or less children
Characteristics
. It is of Semi Synthetic origin and belongs to Protein. It belongs to Immune Globulin pharmacological group.It is weakly acidic drug.
Contraindications
Immune Globulin is contraindicated in conditions like Thrombocytopenia,Ig a deficiency.
Effects
The symptomatic adverse reactions produced by Immune Globulin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Fever, Myalgia, Chills, Urticaria, Erythema, Pain, Facial flushing, Flushing, Hypersensitivity, Angioedema, Tenderness, Muscle stiffiness.
Indications
Immune Globulin is primarily indicated in conditions like Autoimmune disease, Hepatitis, Idiopathic thrombocytopenic purpura, Measles.
Interactions
Immune Globulin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementMumps VaccineAdministration of immune globulins concurrently with Mumps Vaccine may interfere with the expected immune response.Plague VaccineConcurrent use may result in decreased effect.Varicella Vaccine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Positive serological testing result
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store in refrigerator. Do not Freeze.
Warnings
Immune globulin should be used with caution in patients with any pre-existing illness, blood disorders or any allergy, including any drug allergy. It should be used only when clearly needed during pregnancy.
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