Cabergoline

'Cabergotune is ergot derivatives is a dopamine D2-agonist with action and uses similar to bromocriptine. Cabergoline is used after pregnancy to suppress unwanted breast milk secretion and to facilitate conception when infertility is associated with high prolactin level. It may also be used in parkinson''s disease, prolactin-producing tumors and to adjust various hormone levels in certain diseases (ovarian diseases).'

Brands

Adult Dose

Dose: 0.01 to 0.14 mg/kg
Single Dose: 0.075 (0.075)
Frequency: 24 hourly
Route: PO
Instructions: -

Neonatal

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

Paedriatic

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

Characteristics

. It is of Synthetic origin and belongs to Ethylurea. It belongs to D2 agonist pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs pharmacological group.The Molecular Weight of Cabergoline is 451.60.

Contraindications

'Cabergoline is contraindicated in conditions like Peptic ulcer,Hypersensitivity,Hepatic insufficiency,Raynaud''s syndrome.'

Effects

The severe or irreversible adverse effects of Cabergoline, which give rise to further complications include Orthostatic hypotension.The symptomatic adverse reactions produced by Cabergoline are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Fatigue, Nausea, Vomiting, Confusion, Ankle edema, Confusion, dizziness.

Indications

'Cabergoline is primarily indicated in conditions like Excesssive prolactin level, Lactation inhibition, Parkinson''s disease.'

Interactions

Cabergoline is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholClozapineHypoprolactinemic and antiparkinsonian effects of Cabergoline possibly antagonized by antipsychotics (e.g Clozapine).DomperidoneHypoprolactinemic and antiparkinsonian effects of Cabergoline possibly antagonized by Domperidone. ErythromycinPlasma concentration of cabergoline increased by Erythromycin (increased risk of toxicity). LevodopaMethyldopaAntiparkinsonian effect of Cabergoline possibly antagonized by Methyldopa.Metoclopramide (HCl)Hypoprolactinemic effect of Cabergoline possibly antagonized by Metoclopramide.Octreotide (Acetate)VORICONAZOLEConcomitant therapy with a strong CYP3A4 inhibitor may increase concentrations of cabazitaxel.Avoid concomitant therapy These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Interfrence

Risks

Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Storage

Tab Store at room temperature. Protect from Sunlight and Moisture.

Warnings

Cabergoline should be used with caution in patients with medical history, including any allergies (especially drug allergies), liver disease, psychiatric illness, uncontrolled high blood pressure or high blood pressure during pregnancy. Limit alcohol as it may aggravate side effects of this drug. Patients should observe caution while driving or performing tasks requiring alertness. To avoid dizziness and lightheadedness when rising from a seated or lying position, get up slowly. It should be used with caution during pregnancy. It is not recommended during lactation.Reduce dose is severe hepatic impairment

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