Gemcitabine

Gemcitabine is antineoplastic agent, also called as anticancer drug. Gemcitabine is used in the treatment of different cancers such as in palliative treatment of non-small cell lung cancer to slow or stop the growth of abnormal cells. Gemcitabine is used in combination with different anticancer drugs to obtain best therapeutic effects and to reduce toxicity or side effects. It is a pyrimidine antimetabolite used in treatment of solid tumours. It is an analog of eytidine.

Brands
GEMITA GEMITA GEMCIT GEMCIT PAMIGEN PAMIGEN GEMZAR GEMZAR GEMCITABINE GEMCITABINE Trugem Trugem Oncogem Oncogem GEBINA GEBINA
Adult Dose
Dose: 1 g/ sq.meter
Single Dose: 2 (2)
Frequency: As recommended.
Route: IV Inf
Instructions: Once a week for 3 weeks.
Neonatal
Paedriatic
Characteristics
belongs to Diflurocytidine. It belongs to Antiparkinson Agents and Antineoplastic Agnet, Antimetabolite pharmacological group.The Molecular Weight of Gemcitabine is 299.70.
Contraindications
Gemcitabine
Effects
Gemcitabine produces potentially life-threatening effects which include Thrombocytopenia, Used with radical radiotherapy, Pneumonitis, Leukopenia. which are responsible for the discontinuation of Gemcitabine therapy.The symptomatic adverse reactions produced by Gemcitabine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Alopecia, Fever, Constipation, Rashes, StomatitisX, Nausea and vomiting, Thrombocytopenia, Neutropenia, Edema, Anemia, Leukopenia, Pulmonary firbrosis, Alopecia, Oedema, Pruritis, Flu like symptoms, Dypnoea.
Indications
Gemcitabine is primarily indicated in conditions like Breast cancer, Head and neck cancer, Locally advanced or metastatic pancreatic cancer, Lung cancer, Lung cancer and pancreatic cancer, Pancreatic cancer, Treatment of locally advanced or metastatic pancreatic cancer.
Interactions
No data regarding the interactions of Gemcitabine was found.
Interfrence
Transaminase increasedBilirubin increasedAlkaline phosphatase increasedProteinureaBUN increasedCreatinine increased
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Refrigeration and Freezing is not recommended. Inj (reconstituted soln) Store at room temperature.
Warnings
Gemcitabine is not recommended for use during pregnancy or lactation. Immunosuppressent drug should not be given, where possible, to patients with acute infection, dosage reduction or withdrawal should be considered if infection develops, until the infection has been controlled. Blood counts and measurement of hemoglobin concentration should be carried out routinely, help to predict the onset of bone marrow depression. It may cause fever. Discontinue if scure pulmonary toxicity ocurs. Use with caution in hepatic impairement, renal impairement, concurnet radiotheraphy.
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