Fosinopril (Na)

Fosinopril (Na) is ACE inhibitor. It prevents the conversion of certain enzymes in the body. It prevents constriction of blood vessels and lower the blood pressure and makes the heart beat stronger. Fosinopril (Na) is used to treat hypertension (high blood pressure) and heart failure.

Brands
MONOPRIL AKSOPRIL
Adult Dose
Dose: 10 to 40 mg
Single Dose: 25 (25)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Proline. It belongs to Angiotensin converting enzyme inhibitor-ACEI pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.The Molecular Weight of Fosinopril (Na) is 585.60.
Contraindications
Fosinopril (Na)
Effects
The severe or irreversible adverse effects of Fosinopril (Na), which give rise to further complications include Viral infections.The symptomatic adverse reactions produced by Fosinopril (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Fatigue, Nausea, Vomiting, Diarrhea, Myalgia, Pharyngitis, Edema, Chest pain, Paresthesias.
Indications
Fosinopril (Na) is primarily indicated in conditions like Cardiac failure, Congestive heart failure (adjunct), Gastric acid reduction during anaesthesia, Hypertension.
Interactions
Fosinopril (Na) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAspirinAspirin antagonize the hypotensive effect of fosinopril by inhibiting the synthesis of prostaglandin and thus suppressing prostaglandin mediated hemodynamic effect of fosinopril.ModerateIn case of long term therapy blood pressure and renal efficiency should monitor regularly and the lowest therapeutic dosage of aspirin should be used.AspirinRisk of renal impairment when Aspirin (in doses over 300mg daily) given with ACE inhibitors (e.g Fosinopril), also hypotensive effects antagonized.ChlorthalidoneCimetidine (HCl)DigoxinHydrochlorothiazideLithiumMetoclopramide (HCl)NifedipinePropantheline (Br)Propranolol (HCl)Warfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Fosinopril (Na) should be used with caution in patients with a history of angioedema, high blood levels of potassium, kidney disease or kidney dialysis, salt restrictive diet, liver disease and of any drug allergy. Consult the doctor before using salt substitutes or low salt milk. To avoid dizziness and light-headedness when rising from a seated or lying position, get up slowly. Limit alcohol intake and use caution when exercising or during hot weather as these can aggravate dizziness and lightheadedness. This medication is classified as pregnancy category C and should be used only when clearly needed during the first three months of pregnancy and it is not recommended for use during the last six months of the pregnancy. Caution is advised when this medication is used in children and elderly.
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