Fluorometholone

Fluorometholone is a corticosteroid. Chemically Fluorometholone is 9-Fluoro-11β,17-dihydroxy-6a-methylpregna-1, 4-diene-3, 20-dione. Fluorometholone is used in the local treatment of inflammmation when applied as eye drops.


Adult Dose
Dose: 0.1 to 0.25 %w/v
Single Dose: 0.18 (0.175)
Frequency: 12 hourly
Route: Ophthalmic
Instructions: If needed, frequency may be increased to 4 times/day.
Neonatal
Paedriatic
Dose: 0.10%
Single Dose: 0.1 (0.1)
Frequency: As recommended.
Route: Opthalmic
Instructions: As Required
Characteristics
. It is of Synthetic origin and belongs to Corticosteroid. It belongs to Glucocorticoid agonist pharmacological group on the basis of mechanism of action and also classified in Opthalmic Products and Corticosteroid Opthalmic pharmacological group.The Molecular Weight of Fluorometholone is 376.50.
Contraindications
Fluorometholone is contraindicated in conditions like Fungal infection,Viral infection,Herpes simplex keratitis,Herpes simplex infections.
Effects
The severe or irreversible adverse effects of Fluorometholone, which give rise to further complications include Glaucoma, Cataract, Optic neuritis and atrophy, Increased IOP (intraocular pressure).The symptomatic adverse reactions produced by Fluorometholone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Field defects, Visual acuity, Delayed wound healing, Secondary ocular infection.
Indications
Fluorometholone is primarily indicated in conditions like Allergic conjunctivitis, Giant papillary conjunctivitis, Keratitis, Post-operative ocular inflammation, Vernal keratoconjunctivitis.
Interactions
No data regarding the interactions of Fluorometholone was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Eye Susp Store Below 40°C. Protect from Sunlight and Heat.
Warnings
Fluorometholone should be used with caution in patients with active tuberculosis infection of respiratory tract or in untreated fungal, bacterial or systemic viral infections. Corticosteroids should only be used systemically with great caution in the presence of congestive heart failure (CHF), recent myocardial infraction (MI), hypertension, diabetes mellitus, epilepsy, glaucoma, hypothyroidism, liver failure, osteoporosis, peptic ulceration or renal impairment. Children may be at increase risk of some adverse effects, corticosteroid causes growth retardation and prolonged use is rarely justified. Passive immunization is recommended to non-immune patients who do come in contact with chickenpox or measles. Live vaccine should not be given to patients receiving high dose systemic corticosteroid therapy nor for atleast 3 months afterwards, killed vaccine or toxoids may be given, although the response may be attenuated. During prolong treatment with corticosteroids, patients should be examined regularly, sodium intake may need to be reduced and calcium and potassium supplement may be necessary. Patient should carry cards given full details of their corticosteroid therapy. Avoid use during pregnancy. Use nasal steroids with caution until healing has occurred.
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