OMASTIN OMASTIN OMASTIN FLUCON FLUCON FLUGINAL FLUDERM FLUDERM DEYEAST DEYEAST DEYEAST DIFLUCAN DIFLUCAN DIFLUCAN DIFLUCAN DIFLUCAN FLU-Z FLU-Z ZOLANIX DEROCON DEROCON DEROCON DEROCON FCOZOLE FCOZOLE FCOZOLE FCOZOLE FCOZOLE NOTOCAN NOTOCAN NOTOCAN FUNGICURE F-ZOLE F-ZOLE FUNGANIL CANDICAN FUNGIMED FASICAL HIFLUZOLE MONOCARE COZOLE COZOLE LEUCON LEUCON FYCOZOLE VZOLE COHEIM FLUCO-Z FAVRIZOL FAVRIZOL GENIEL CANDIRID HIFLUCAN SKIF SKIF CANZOLE CANZOLE DOTEX NIDACON GRAFAZOLE GRAFAZOLE TRIAZOLIN PULCON FUNGIX FUNGONE LUMEN LUMEN CANDIA CARATIN REXOLE REXOLE TRAC TRAC V-CON ZOLDI FLUNAZ FLUKA FLUCOVAL FUNGVEL FUNGUS PLUS RYZOL LUCONAZOL FLUCOADVAN FLOC FLOC FLUCAL LARGON LARGON CONSAL FLUCANOL FLUCOAIM FLUCOROWN FLUCOSAF FLUCOSAF FLUCOZOLE FLUNAZ FUNGAS FUNZIL NO-FUNG NO-FUNG NT.FUNGAL SAYFLUC UCONAZOL DECONAZOL FUNFIL MYCOLE MYCOLE MYCOLE NAZOLE ONAMED ONLEZOL ONLEZOL TRICAN ALFUMET ARSOZOLE AXICON BECONAZOLE CONA DIFLOZE ECONAZOL FLUIN FUNGIFIGHT FUNGIFIGHT FUNGIFIGHT FUNGIFIGHT INFLUDERM LUNIM ROTAZOL TECHNOZOLE FLUZOLE H-ZOLE FLOZEX FUGIX FUGIX FUGIX COZIL COZIL FLOCOSH RANZO FLUGAL FLUZIC

Dose: 100 to 800 mg /day
Single Dose: 450 (450)
Frequency: 24 hourly
Route: IV
Instructions: for Mucocutaneous candidiasis

Dose: 1 to 2 mg/kg
Single Dose: 1.5 (1.5)
Frequency: 24 hourly
Route: Slow IV
Instructions: -

Dose: 1 to 2 mg/kg
Single Dose: 1.5 (1.5)
Frequency: 24 hourly
Route: Slow IV
Instructions: -

Fluconazole also known as diflucan, diflucan, diflucan. . It is of Synthetic origin and belongs to Triazol. It belongs to Antifungal Agent, Parental pharmacological group.The Molecular Weight of Fluconazole is 306.30. Its pKa is 2.03.

Fluconazole

The severe or irreversible adverse effects of Fluconazole, which give rise to further complications include Alopecia, Thrombocytopenia, Elevated alkaline phosphatase concentration, Eelvated hepatic enzymes, Hyperlipidemia, Elevated alkaline phosphatase concentration.Fluconazole produces potentially life-threatening effects which include Severe skin reactions in AIDS, Hepatic necrosis, Death. which are responsible for the discontinuation of Fluconazole therapy.The signs and symptoms that are produced after the acute overdosage of Fluconazole include Hallucinations, Paranoid psychosis.The symptomatic adverse reactions produced by Fluconazole are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Diarrhea, Abdominal pain, Rashes, Hypokalemia, Pallor, Anaphylaxis, Leucopenia, dizziness.

Fluconazole is primarily indicated in conditions like Adjunctive therapy without valproate, Candidiasis, Cryptcoccal meningitis, Fungal infection, Neurogenic bladder, Oropharangeal candidiasis, Parkinsonism, Pityriasis versicolor, Vaginal infections, and can also be given in adjunctive therapy as an alternative drug of choice in Bone marrow transplantation, Cryptococcal infections including meningitis, Esophagitis, Urinary tract infection.

Fluconazole is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlfentanil (HCl)AliskirenAlprazolamAmitriptyline (HCl)Fluconazole inhibit CYP450 3A4 isoenzyme which decrease Amitriptyline clearance leads to CNS toxicity and prolong QT interval. ModerateAdjust amitriptyline dose and monitor its serum levels.ArtesunateConcurrent use may increase artesunate serum concentrations. AstemizoleFluconazole is a weak inhibitor of CYP450 3A4 enaymatic pathway and may not impair the clearence of astemizole at usual doses.ModerateLoratadine, cetirizine and fexofenadine is considered safer alternatives of astemizole.BosentanPlasma concentration of Bosentan possibly increased by Fluconazole; avoid concomitant use.MajorCelecoxibChlorpropamideFluconazole decrease chlorpropamide clearance by inhibiting CYP450 3A4 thus increases its plasma concentration that leads to marked hypoglycemia. ModerateRegular checking of blood glucose level and chlorpropamide dose adjustment is required when given with fluconazole.CisaprideFluconazole by inhibiting CYP450 3A4 increases plasma concentration of cisapride thus prolong QT interval leads to ventricular arrhythmias,cardiac arrest and sudden death may also occur.MajorCoadministration of both drugs sre contraindicated.Clorazepate (K)Cyclosporin AHigh doses(more than 200 mg per day) of fluconazole can increase serum concentration and toxicity of cyclosporine through CYP450 3A4 hepatic and or gut wall metabolism inhibition.Moderatedose adjustmnet and monitoring of renal function and serum cyclosporine levels are required.FosphenytoinHydrochlorothiazideLacosamideLoratadineFluconazole increases the AUC upto 180% for loratadine and upto 56%for its active metabolite by inhibiting its metabolism. MinorLoratadine considered as safer drug for use with fluconazole.Losartan (K)Fluconazole increases the plasma concentration of losartan but decreases its active metabolite by inhibiting CYP450 2C9, an isoenzyme that convert losartan to its metabolite.ModerateClosely monitor for blood pressure whenever start, discontinue or change the dose of fluconazole. Itroconazole, ketoconazole and terbinafine are considered more safer alternatives of fluconazole and eprosartan is considered more safer alternative of losartan.Nortriptyline (HCl)Phenytoin (Na)Fluconazole inhibit CYO450 2C9 and 2C19 hepatic metabolism thus increases phenytion serum levels result in phenytoin toxicity.ModerateMonitoring of serum phenytoin levels,patient response and tolerance.Adjust dose of phenytoin.QuetiapineRepaglinideFluconazole may increase the levels/effects of repaglinide.RifabutinRifampicinRifampicin induce metabolism of fluconazoleRitonavirFluconazole responsible for CYP450 3A4 inhibition can cause slight increase in ritonavir plasma concentration.MinorNo such measures should be taken in coadministration of these drugs.SaccharomycesFluconazole may inactivate Saccharomyces organisms.It has been recommended that Saccharomyces be administered at least 1 hour before or 2 hours after an antifungal dose.SulfapyridineConcurrent use with sulfonamides may result in an increased incidence of hepatotoxicity. Patients, especially those on prolonged administration or those with a history of liver disease.Should be carefully monitored.SulphamethoxazoleTerfenadineFluconazole increases the plasma concentration of terfenadine by inhibiting CYP450 3A4-mediated first-pass metabolism result in high plasma level may be associated with prolongation of QT interval on the ECG, ventricular arrythmia, cardiac arrest and sudden death.MajorCoadministration of terfenadine with higher doses of fluconazole is considered contraindicated. Loratadine, cetirizine or fexofenadine are safer alternatives of terfenadine.Theophyllinetheophylline decrease mean plasma concentration of fluconazolelook for sign and symptoms of theophylline toxicityTorasemideFluconazole, a strong CYP2C9 inhibitor, may increase the serum concentration of Torasemide, a CYP2C9 substrate, by decreasing Torasemide metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Torasemide if Fluconazole is initiated, discontinued or dose changed.VORICONAZOLEFluconazole may increase the serum concentration of voriconazole by decreasing its metabolism. Consider alternate therapy or monitor for QTc prolongation Warfarin (Na)Fluconazole may decrease the metabolism, via CYP isoenzymes, of Warfarin. ModerateDelayedMonitor for increased therapeutic/toxic effects of Warfarin if Fluconazole is initiated/dose increased, or decreased effects if Fluconazole is discontinued/dose decreased.ZidovudineFluconazole decreases the clearence of zidovudine and enhances its elimination half life by inhibiting hepatic metabolism.ModerateClosely monitor for zidovudine toxicity. Reduce the dose of zidovudine or discontinue fluconazole if necessary. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Increased Alkaline Phosphatase Bilirubin (increased level)

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab, Oral Susp Store Below 40°C. Protect from Sunlight and Moisture.

Fluconazol should be used with caution in patients with liver disease, kidney disease or of any drug allergy. This medication should be used only when clearly needed during pregnancy. Avoid fluconazole during lactation.childern not recommended under one year.Dose adjusted in renal impairment.