Buspirone (HCl)

Buspirone (HCl) is anxiolytic agent and a 5-HT 1 agonist. Buspirone (HCl) is a new non-benzodiazepine. It relieves nervousness, anxiety. Unlike benzodiazepines the drug has less side effects.


Adult Dose
Dose: 5 mg
Single Dose: 5 (5)
Frequency: 12 hourly
Route: PO
Instructions: Increased by 5 mg every 2-3 days.
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Pyrimidinyl piperazinyl decane. It belongs to 5HT-1A antagonist pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs and Antianxiety Agent pharmacological group.The Molecular Weight of Buspirone (HCl) is 422.00. Its pKa is 1.22, 7.32.
Contraindications
Buspirone (HCl) is contraindicated in conditions like Epilepsy,Hypersensitivity,Renal impairment,Hepatic impairment.
Effects
The signs and symptoms that are produced after the acute overdosage of Buspirone (HCl) include Nausea, Vomiting, Drowsiness, Gastric distress, Dizziness, Miosis.The symptomatic adverse reactions produced by Buspirone (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Vomiting, Gastric complaints, Sleeplessness, Uneasiness.
Indications
Buspirone (HCl) is primarily indicated in conditions like Generalized anxiety disorder, Non-specific anxiety symptoms, Suppression of transplant rejection.
Interactions
Buspirone (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholAmisulprideIncreased sedative effects when antipsychotics (e.g Amisulpride) given with hypnotics (e.g Buspirone)DigoxinIncreases plasma concentration of Digoxin.Diltiazem (HCl)Erythromycinplasma concentration of Buspirone increased by Erythromycin.MajorReduce dose of Buspirone.HaloperidolBuspirone increases plasma concentration of Haloperidol.Iproniazid PhosphateTheoretical potential for BUSPIRONE HYDROCHLORIDE increasing the HYPERTENSIVE effect of IPRONIAZID. Potential risk. AvoidItraconazoleMethotrimeprazine (Maleate)ParoxetinePromazine (HCl)SulpirideTrazodone (HCl)Verapamil (HCl)VORICONAZOLEVoriconazole may increase the serum concentration of buprenorphine by decreasing its metabolismMonitor for changes in the therapeutic and adverse effects of buprenorphine if voriconazole is initiated, discontinued or dose changed These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.
Warnings
Buspirone should be used with caution in patients with kidney or liver impairment. Patient should observe caution while driving or performing other task requiring alertness.
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