Estradiol (Valerate)

Estradiol (Valerate) is the most potent naturally occuring ovarian and placental estrogen in mammals. Estradiol (Valerate) is has also been produced semi-synthetically. iteffective for replacement therapy in women who is deficient of hormone and used to treat symptoms associated with menopause and conditions in which hormone levels are low and to prevent osteoporosis (bone loss). itadminstered intramuscularly.

Brands
PROGYLUTON PROGYLUTON DEPOT PROGYNOVA FEMI JECT ESTRANOR BEDOL PROGENS TAB NORESTRA
Adult Dose
Dose: 0.5 to 2 mg/ kg
Single Dose: 1.2 (1.25)
Frequency: As recommended.
Route: Implants
Instructions: For about4 to 8 months
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
Estradiol (Valerate) also known as Oestradiol valerate. . It is of Synthetic origin and belongs to Steroid. It belongs to Oestrogen Agonist pharmacological group on the basis of mechanism of action and also classified in Sex Hormones and Estrogen Derivatives pharmacological group.The Molecular Weight of Estradiol (Valerate) is 356.50.
Contraindications
Estradiol (Valerate) is contraindicated in conditions like Gall stones,Fibroids,Endometriosis,Estrogen-dependent cancer,Undiagnosed vaginal bleeding,Venous thromboembolic disease.
Effects
The symptomatic adverse reactions produced by Estradiol (Valerate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Skin reactions, Impotence, Weight gain, Nipple tenderness, Edema, Gynecomastia, Breast tenderness, Hypercalcemia, Withdrwal bleeding.
Indications
Estradiol (Valerate) is primarily indicated in conditions like Estrogen-responsive prostate carcinoma, Menopausal symptoms, Osteoporosis, and can also be given in adjunctive therapy as an alternative drug of choice in Breast cancer.
Interactions
Estradiol (Valerate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholCarbamazepineCyclosporin AGriseofulvinPhenindionePhenobarbitonePhenytoin (Na)PrimidoneRepaglinideEstradiol (Valerate) may increase repaglinide concentrations. RifampicinThiamine HCl (Vitamin B1)Estradiol (Valerate) may decrease levels of some B vitamins, vitamin C, and zinc in the body. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Impairment of Glucose Tolerance
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Between 15°C-30°C. Protect from Sunlight.
Warnings
Estradiol should be used with caution in patients with medical history, including family medical history, especially breast lumps and cancer, high blood pressure, diabetes, asthma, epilepsy, migraine headaches, liver, heart or kidney disease, depression, toxemia (high blood pressure during pregnancy), jaundice during pregnancy, excessive weight gain and fluid retention during the menstrual cycle or if have uterine fibroid tumors. Before having surgery, tell the doctor about the use of the drug. Do not use this medication during pregnancy or lactation. This medication may cause fetal harm. Cigarette smoking can increase the chance of blood clots while using this medication (especially in women pass the age of 35). Higher strengths are more likely to cause melasma (darkening of skin), sunlight may intensify this darkening, so avoid prolonged sun exposure and sunlamps. Consult the doctor regarding use of sunscreens and protective clothing.
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