Zolpidem (Tartrate)

Zolpidem (Tartrate) is a non-benzodiazepine sedative-hypnotic for the short-term treatment of insomnia. Although chemically unrelated to other hypnotics such as the benzodiazepines or barbiturates, zolpidem does share some pharmacological actions with these drugs. Unlike the benzodiazepines, zolpidem produces muscle relaxation and anticonvulsant effects only at doses much higher than the hypnotic dose. Zolpidem has a short half-life and no active metabolites. Therefore, a next-day "hangover" effect and CNS depression are less for zolpidem than the barbiturates. Treatment of insomnia with zolpidem should be restricted to a period of 7-10 days. Zolpidem received FDA approval in 1993.

Brands
STILNOX ZOLP SIESTA XOLNOX AMBIN ZILNOX ZOPALET ZORELAX SOMNIA
Adult Dose
Dose: 10 mg
Single Dose: 10 (10)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
belongs to Imidazopyridine. It belongs to Chloride Channel opener (Gaba operated) pharmacological group on the basis of mechanism of action and also classified in Sedatives and Hypnotics pharmacological group.The Molecular Weight of Zolpidem (Tartrate) is 764.90.
Contraindications
Zolpidem (Tartrate) is contraindicated in conditions like Myasthenia gravis,Psychosis,Pulmonary insufficiency,Respiratory depression,Sleep apnea syndrome.
Effects
The severe or irreversible adverse effects of Zolpidem (Tartrate), which give rise to further complications include Dementia.The symptomatic adverse reactions produced by Zolpidem (Tartrate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Confusion, GI upset, Depression, Tremor.
Indications
Zolpidem (Tartrate) is primarily indicated in conditions like Insomnia, Nausea, vertigo, labyrinthine disorders.
Interactions
Zolpidem (Tartrate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholCarbamazepineIsoniazidNelfinavirNevirapinePhenobarbitonePhenytoin (Na)RifampicinRitonavirVORICONAZOLEVoriconazole may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Heat.
Warnings
Zolpidem hemitartrate should be used during pregnancy or lactation only if clearly needed. It should be used with caution in patients with any pre-existing kidney disease, liver disease, lungs disease, history of drug dependence or depression, breathing problems or if have any allergy.
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