Zolmitriptan

Zolmitriptan is a selective serotonin (5-HT) antagonist, used in the treatment of acute migraine attack but it does not prevent migraine attack.


Adult Dose
Dose: 2.5 mg
Single Dose: 2.5 (2.5)
Frequency: As recommended.
Route: PO
Instructions: As Required
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Aminoindole. It belongs to 5HT-1 agonist pharmacological group on the basis of mechanism of action and also classified in Antimigraine and Serotonin 5HT1D Receptor Agonist pharmacological group.The Molecular Weight of Zolmitriptan is 287.40.
Contraindications
'Zolmitriptan is contraindicated in conditions like Hypertension,Prinzmetal''s angina.'
Effects
The severe or irreversible adverse effects of Zolmitriptan, which give rise to further complications include Angina, Myocardial infarction.The symptomatic adverse reactions produced by Zolmitriptan are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Nausea, Muscle weakness, Asthenia, SomnolenceX, Warmth feeling, Heaviness.
Indications
Zolmitriptan is primarily indicated in conditions like Migraine, Treatment of acute migraine attacks.
Interactions
Zolmitriptan is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCimetidine (HCl)Fluvoxamine (Maleate)Vortioxetineincreases toxicity of vortioxetineMajoruse alternative These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Cardiac / Hypertensive Patients.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Between 20°C-25°C. Protect from Sunlight and Moisture.
Warnings
Zolmitriptan should be used with caution in patients with allergy (especially drug allergy), heart or blood vessel problems, high blood pressure or cholesterol, intestine or liver disease, diabetes, smoking history or family history of heart problems. Caution is advised before performing hazardous tasks (e.g.driving) while using this drug. It should be used only when clearly needed during pregnancy.
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