Vinorelbine (Tartrate)

Vinorelbine (Tartrate) is a semi-synthetic, intravenous antineoplastic (anticancer) agent, belongs to the class of vinca alkaloids. Vinorelbine (Tartrate) is a derivative of vinblastine and has structural modifications distinctly different from other vinca alkaloids. The spectrum of activity of vinorelbine is similar to either vincristine or vinblastine, however, vinorelbine may have less neurotoxicity than vincristine. Vinorelbine was approved by the FDA for treatment of advanced non-small cell lung cancer (NSCLC) December 22, 1994. its activity in breast cancer is notable but still requires further investigation. Vinorelbine (Tartrate) is used alone or in combination with other anticancer drugs in the treatment of certain cancers such as lung cancer, breast cancer, ovarian cancer.

Brands
VINELBINE VINELBINE NAVELBINE NAVELBINE EBERELBIN EBERELBIN VINKEBIR VINKEBIR
Adult Dose
Dose: 25 to 30 mg/ sq.meter
Single Dose: 28 (27.5)
Frequency: As recommended.
Route: IV
Instructions: Once in a Week
Neonatal
Paedriatic
Characteristics
belongs to Vinca Alkaloid. It belongs to Mitotic Inhibitors and Antineoplastic Agent, Plant Derivative pharmacological group.The Molecular Weight of Vinorelbine (Tartrate) is 1079.10.
Contraindications
Vinorelbine (Tartrate) is contraindicated in conditions like Bacterial infections,Bone marrow depression.
Effects
The severe or irreversible adverse effects of Vinorelbine (Tartrate), which give rise to further complications include Bone marrow depression.
Indications
Vinorelbine (Tartrate) is primarily indicated in conditions like Lung cancer, and can also be given in adjunctive therapy as an alternative drug of choice in Advanced breast cancer.
Interactions
Vinorelbine (Tartrate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementVORICONAZOLEVoriconazole may increase the serum concentration of Vinorelbine by decreasing its metabolism. Consider alternate therapy to avoid Vinorelbine toxicity. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store in refrigerator. Do not Freeze.
Warnings
Vinorelbine should be used with caution in patients with any pre-existing liver disease, kidney disease, lung disease, breathing trouble or any allergy. Because it may cause bleeding be careful when brushing or flossing teeth. Avoid contact with people that may have colds or flu or recently received the oral polio vaccine. Vinorelbine must be handled carefully because it can irritate the skin. Vinorlbine should be avoided if possible during pregnancy or lactation. A reliable form of contraception is recommended for use during therapy with this medication.
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