Topotecan (HCl)

Topotecan (HCl) is intravenous antineoplastic (anticancer) agent. Topotecan, similar to irinotecan, is a derivative of camptothecin (CPT), a cytotoxic plant alkaloid isolated from the Chinese tree Camptotheca acuminata. it, along with irinotecan, is the first of a new class of antineoplastics, the topoisomerse I inhibitors. Topotecan is a second-line treatment for ovarian carcinoma. It has also been investigated for treatment of non-small-cell lung carcinoma, and for chronic myelomonocytic leukemia (CMML). As a single agent, topotecan offers equal response rates to other antineoplastics for lung or ovarian carcinomas. its role in combination therapy has not yet been well defined. Topotecan was FDA approved May 29, 1996 for the treatment of metastatic ovarian carcinoma.

Brands
HYCAMTIN TOPOTEL TOPOKEBIR
Adult Dose
Dose: 1.5 mg/sq.meter
Single Dose: 3 (3)
Frequency: 24 hourly
Route: IV Inf
Instructions: Initially for 5 Days
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Semi synthetic origin and belongs to Alkaloid. It belongs to Antineoplastic Agent, Plant Derivative pharmacological group.The Molecular Weight of Topotecan (HCl) is 457.90.
Contraindications
Topotecan (HCl) is contraindicated in conditions like Bone marrow depression.
Effects
The severe or irreversible adverse effects of Topotecan (HCl), which give rise to further complications include Thrombocytopenia, Hyperbilirubinemia.The symptomatic adverse reactions produced by Topotecan (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Fatigue, Alopecia, Malaise, GI disturbance.
Indications
Topotecan (HCl) is primarily indicated in conditions like Ovarian cancer, Small cell lung cancer, and can also be given in adjunctive therapy as an alternative drug of choice in Metastatic ovarian cancer.
Interactions
No data regarding the interactions of Topotecan (HCl) was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store at room temperature, Between 20°C-25°C. Protect from Sunlight.
Warnings
Topotecan is not recommended for use during pregnancy or lactation. Immunosuppressent drug should not be given, where possible, to patients with acute infection, dosage reduction or withdrawal should be considered if infection develops, until the infection has been controlled. Blood counts and measurement of hemoglobin concentration should be carried out routinely, help to predict the onset of bone marrow depression. It must be handled with great care and avoid contact with skin and eyes, and should not be inhaled. Avoid use in patient with impaired kidney or liver function.
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