Bumetanide

Bumetanide is a loop diuretic and a sulfonamide derivative. Bumetanide is used as an antihypertensive agent. It has a carboxyl group with a sulfamoyl moiety in the meta position. A halide or phenoxy substitution is present at carbon 4, and a substituted amino group is present at carbon 2 or 3. It increases the urination and decrease the amount of water retained in the body.Bumetanide is administered orally, intramuscularly or intravenously. Bumetanide is a sulfonamide-type loop diuretic used in the management of edema associated with congestive heart failure, cirrhosis, and renal disease such as nephrotic syndrome.

Brands
BURINEX-K XURIN- K
Adult Dose
Dose: 0.5 to 1 mg
Single Dose: 0.75 (0.75)
Frequency: 24 hourly
Route: PO,Slow IV
Instructions: Every 2-3 Hours in a Day
Neonatal
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Sulfamoylbenzoic acid. It belongs to Na-K-Cl triple cotransport inhibitor pharmacological group on the basis of mechanism of action and also classified in Diuretic Loop pharmacological group.The Molecular Weight of Bumetanide is 364.40. Its pKa is 0.3, 4, 10.
Contraindications
Bumetanide is contraindicated in conditions like Gout,Renal failure,Anuria,Hepatic coma,Severe elecrolyte imbalance.
Effects
The severe or irreversible adverse effects of Bumetanide, which give rise to further complications include Encephalopathy, Ototoxicity.Bumetanide produces potentially life-threatening effects which include Hypersensitivity reactions, Electrolyte and volume depletion, Electrolyte disturbances, Volume disturbances. which are responsible for the discontinuation of Bumetanide therapy.The signs and symptoms that are produced after the acute overdosage of Bumetanide include Electrolyte imbalance, Volume depletion, Cardiovascular shock, Embolism, Thrombosis.The symptomatic adverse reactions produced by Bumetanide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Diarrhea, Abdominal pain, Dry mouth, Rashes, Hypotension, Musculoskeletal discomfort, Diaphoresis, Renal failure, Nipple tenderness, Premature ejaculation, Erectile dysfunction, Arthralgia, Ear pain.
Indications
Bumetanide is primarily indicated in conditions like Congestive heart failure, Hypercalcaemia, Hypertension, Nephrotic syndrome, Oedema, Oliguria due to renal failure, Prohylaxis of acid aspiration in obstetric patients, Pulmonary edema.
Interactions
Bumetanide is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementArbekacinBendrofluazideCeftibutenDigoxinBumetanide may enhance the adverse/toxic effect of Digoxin. This by increasing the risk of hypokalemia. ModerateMonitor for increased toxic effects of Digoxin if Bumetanide is initiated or the dose is increased. The use of a potassium-sparing diuretic might be considered to minimize potassium loss. Likewise, potassium supplementation, along with careful monitoring of serum potassium and possibly Digoxin concentrations, might be helpful. IndomethacinLithiumMetolazoneMilrinone (Lactate)PerindoprilInfrequent reports of BUMETANIDE increasing the HYPOTENSIVE effect of Perindopril Erbumine. ModeratePirbuterol (Acetate)The ECG changes or hypokalemia that may result from the administration of Bumetanide can be acutely worsened by Pirbuterol (Acetate), especially when the recommended dose of the Pirbuterol (Acetate) is exceeded.Although the clinical significance of these effects is not known, caution is advised in the coadministration of beta-agonists with Bumetanide.ProbenecidSodium BicarbonateThiamine HCl (Vitamin B1)Bumetanide have been associated with decreased thiamin levels in the body by increasing urinary excretion and possibly by decreasing absorption and increasing metabolism. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Inj Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Bumetanide should be used with caution in patients with medical history, including any allergies (especially drug allergies), liver or kidney diseases, blood disorders or hearing impairments. Dizziness on standing may occur, to avoid dizziness or lightheadedness when rising from a seated or lying position, get up slowly. This medication should be used only when clearly needed during pregnancy or lactation. Caution is advised when this drug is used in the elderly patients.
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