Topiramate

Topiramate is a sulphamate-substituted monosaccharide, an antiepileptic agent. Topiramate is structurally different from all other antilepileptic drugs. Topiramate is used as an adjunctive therapy for refaractory partial seizures and primary generalized tonic-clonic seizures. Withdrawal of it therapy or transition to or from another type of antiepileptic therapy should be made gradually to avoid exacerbation of seizures.


Adult Dose
Dose: 200 mg
Single Dose: 200 (200)
Frequency: 12 hourly
Route: PO
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Sulphamate Monosaccharides. . The Molecular Weight of Topiramate is 339.40.
Contraindications
Topiramate
Effects
The symptomatic adverse reactions produced by Topiramate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Ataxia, Nervousness, Confusion, Pharyngitis, Depression, Edema, Hot flushes, SomnolenceX, Chest pain, Backache, Rigors, Xerostomia, Speech problems.
Indications
Topiramate is primarily indicated in conditions like Adjunctive treatment of partial seizures, Oedema, Seizures, Seizures associated with lennox gastaut syndrome.
Interactions
Topiramate is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCarbamazepineCarbamazepine lowers the plasma concentration of topiramate.CarbamazepineDigoxinFosphenytoinPhenytoin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Topiramate should be used with caution in patients with any allergy (especially drug allergies), kidney or liver disease. Drink plenty of fluids to decrease the chance of kidney stones. Patient should observe caution while driving or performing other tasks that require mental alertness. It should be used with caution during pregnancy and lactation.
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