Tizanidine

Tizanidine is a alpha-2 receptor agonist, used for muscle relaxation associated with muscle spasms. Tizanidine is used in patient with spinal injury or disease and in multiple sclerosis.


Adult Dose
Dose: 2 to 4 mg
Single Dose: 3 (3)
Frequency: 8 hourly
Route: PO
Instructions: Max. 36mg/day for neurological disorders.
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
belongs to Benzothiadiazolamine. It belongs to Alpha adrenergic agonist pharmacological group on the basis of mechanism of action and also classified in Gastrointestinal Anticholinergics/Antispasmodics and Antispasmodic Agent pharmacological group.The Molecular Weight of Tizanidine is 209.20.
Contraindications
Tizanidine
Effects
The severe or irreversible adverse effects of Tizanidine, which give rise to further complications include Hepatitis.The symptomatic adverse reactions produced by Tizanidine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Drowsiness, Fatigue, Nausea, Insomnia, Dry mouth, Hallucination, Muscle weakness, SomnolenceX, GI disturbance.
Indications
Tizanidine is primarily indicated in conditions like Cerebral palsy, Cerebrovascular accident, Myelopathy, Nausea and vomiting (acute attacks), Sclerosis, Spasticity, Spastiicity associated with multiple sclerosis.
Interactions
Tizanidine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholDiazoxideEnhanced hypootensive effect when Diazoxide given with Tizanidine.DigoxinEnoxacinFosphenytoin These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Tizanidine should be used with caution in patients with any allergy, low blood pressure, liver, heart or kidney disease or eye disease. Limit the use of alcohol as alcohol may intensify the dizziness and drowsiness effects of tizanidine. It should be used caution while driving or performing other tasks requiring alertness, such as operating machinery. It should be used only when clearly needed during pregnancy. Caution is advised when this drug is used in the elderly persons.
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