Ticlopidine (HCl)

Ticlopidine (HCl) reduces platelet aggregation. Ticlopidine (HCl) acts by producing changes (may be irreversible) to the platelet membrane reducing their ability to form blood clots with fibrin. itused in combination with other antiplatelet drugs to reduce the risk of further thrombolytic events. itperticularly useful in patients who cannot tolerate aspirin.

Brands
TEKOPIN TEOLID TICLOPOLI TICLID ZICLODIN CLOPIDINE TICLOR
Adult Dose
Dose: 250 mg
Single Dose: 250 (250)
Frequency: 12 hourly
Route: PO
Instructions: With meals.
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
belongs to Pyridine. . The Molecular Weight of Ticlopidine (HCl) is 300.20.
Contraindications
Ticlopidine (HCl) is contraindicated in conditions like Thrombocytopenia,GI ulceration,Leukopenia,Agranulocytosis,Hemorrhagic diathesis.
Effects
The severe or irreversible adverse effects of Ticlopidine (HCl), which give rise to further complications include Aplastic anemia, Stevens johnson syndrome, Jaundice, Hepatic necrosis, Renal failure, Peptic ulceration.The symptomatic adverse reactions produced by Ticlopidine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Weakness, Dizziness, Headache, Vomiting, Anorexia, Rashes, Pruritus, Pain, Hematuria, Thrombocytopenia, Neutropenia, GI hemorrhage, Pancytopenia, Increased intracranial pressure, Menorrhagia.
Indications
Ticlopidine (HCl) is primarily indicated in conditions like Cardiac stroke, Ischaemic heart disease, Thromboembolism.
Interactions
Ticlopidine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCimetidine (HCl)FosphenytoinNadroparin (Ca)Concurrent use may increase the risk of hemorrhage.Oligomeric ProcyanidinConcurrent use of high doses of OPCs with Ticlopidine (HCl) might cause a risk of excessive bleeding. Phenytoin (Na)TheophyllineTiaprofenic AcidTiclopidine (HCl) can cause an increased risk of bleeding. Tinzaparin SodiumConcurrent use may increase the risk of bleeding.If coadministration is essential, close clinical and laboratory monitoring of these patients is advised. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Interferes with LFT
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Ticlopidine should be used with extreme caution in patients with history of bleeding disorder, ulcers, liver problems or low blood count. It should be used with caution during pregnancy or lactation.
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