Budesonide

Budesonide is a synthetic corticosteroid. Budesonide is used by inhalation in moderate to severe asthma that is unresponsive to other drugs. Inhaled corticosteroid works as an anti-inflammatory agent in the nasal mucosa to treat symptoms of allergies including nasal congestion, itching, runny nose or sneezing.

Brands
PULMICORT PULMICORT COMBIVAIR COMBIVAIR COMBIVAIR
Adult Dose
Dose: 200 to 800 mcg
Single Dose: 500 (500)
Frequency: 12 hourly
Route: Inhalation
Instructions:
Neonatal
Dose: 6.25 to 12.5 ug/kg
Single Dose: 9.4 (9.375)
Frequency: 12 hourly
Route: Inhalation
Instructions:
Paedriatic
Dose: 5 to 20 ug/kg
Single Dose: 12 (12.5)
Frequency: 12 hourly
Route: Inhalation
Instructions: -
Characteristics
. It is of Synthetic origin and belongs to Corticosteroid. It belongs to Glucocorticoid agonist pharmacological group on the basis of mechanism of action and also classified in Corticosteroid Nasal pharmacological group.The Molecular Weight of Budesonide is 430.50. Its pKa is not relevant.
Contraindications
Budesonide is contraindicated in conditions like Diabetes mellitus,Glucoma,Hypertension,Osteoporosis,Pulmonary TB,Fungal or viral respiratory infection.
Effects
The severe or irreversible adverse effects of Budesonide, which give rise to further complications include Peptic ulceration, Osteoporosis, Ocular hypertension, Cushing like features, Suppression of adrenal function.The symptomatic adverse reactions produced by Budesonide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Skin reactions, Insomnia, Irritation of throat, Coughing, Candidiasis, Agitation, GI disturbance.
Indications
'Budesonide is primarily indicated in conditions like Asthma, Crohn''s disease, Dermatosis, Eczema, Rhinitis, Ulcerative colitis, and can also be given in adjunctive therapy as an alternative drug of choice in Less severe asthma, Liver transplant, Ventricular fibrillation, pulseless ventricular tachycardia.'
Interactions
Budesonide is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCholestyraminePioglitazoneVORICONAZOLEVoriconazole may increase the serum concentration of budesonide by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of budesonide if voriconazole is initiated, discontinued or dose changed. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Aerosol Store Below 40°C. Protect from Moisture.
Warnings
Budesonide should be used with caution in patients with medical history including all illnesses, infections, recent exposures to contagious diseases (e.g. chicken pox), glaucoma, cataracts or any allergies, especially of any drug allergy. If patients are switching or have switched within the last 9 months from an oral corticosteroid to an inhaled one and experience loss of appetite, nausea, vomiting, unusual tiredness, headache, fever, dizziness, joint and muscle pain or weight loss, so should contact the doctor, there may need to increase dose of the oral corticosteroid temporarily or start taking it again. Children and teenagers should be monitored for proper growth patterns while using any corticosteroid medicine. This medication should be used only when clearly needed during pregnancy or lactation.
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