Brompheniramine (Maleate)

Brompheniramine (Maleate) is antihistaminic agent. Brompheniramine (Maleate) is probably effective for temporary relief of hay fever (allergic rhinitis affecting the mucous membranes of the eyes and respiratory tract caused by pollen of certain plants) and upper respiratory allergic symptoms, such as itchy, watery eyes, sneezing.

Brands
Adult Dose
Dose: 0.114 mg/kg
Single Dose: 0.11 (0.114)
Frequency: 8 hourly
Route: PO
Instructions: -
Neonatal
Dose: 0.1 to 0.25 mg/kg
Single Dose: 0.18 (0.175)
Frequency: 8 hourly
Route: oral
Instructions:
Paedriatic
Dose: 0.1 to 0.25 mg/kg
Single Dose: 0.18 (0.175)
Frequency: 8 hourly
Route: Oral
Instructions: -
Characteristics
. It is of Synthetic origin and belongs to Propylamine. It belongs to H1-antagonist pharmacological group on the basis of mechanism of action. The Molecular Weight of Brompheniramine (Maleate) is 435.30. Its pKa is 3.9.
Contraindications
Brompheniramine (Maleate) is contraindicated in conditions like Porphyria,General dose.
Effects
The severe or irreversible adverse effects of Brompheniramine (Maleate), which give rise to further complications include Hallucinations, Brain damage or epilepsy, Aggression, Sleep disturbances, Grand-mal seizures.Brompheniramine (Maleate) produces potentially life-threatening effects which include Agranulocytosis. which are responsible for the discontinuation of Brompheniramine (Maleate) therapy.The signs and symptoms that are produced after the acute overdosage of Brompheniramine (Maleate) include Hypotension, Convulsions, Coma.The symptomatic adverse reactions produced by Brompheniramine (Maleate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dry mouth, Blurred vision, Sedation.
Indications
Brompheniramine (Maleate) is primarily indicated in conditions like Allergic conjunctivitis, Allergic rhinitis, Dermatitis, NSAID associated ulceration, Urticaria, and can also be given in adjunctive therapy as an alternative drug of choice in Asthma.
Interactions
No data regarding the interactions of Brompheniramine (Maleate) was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Elixir Store Below 40°C. Do not Freeze. Protect from Sunlight and Moisture. Tab, Caps, Inj Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Brompheniramine should be used with caution in bone marrow depression. Patients should observe caution while driving or performing other task requiring alertness because it may cause drowsiness. It should be used with caution in patients with urinary retention, history of bronchial asthma, hyperthyroidism, cardiovascular or liver disease. It should be used with caution in person with acute or chronic respiratory impairment, especially in children. Do not administer subcutaneously, because irritation or lesion may occur.
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