Tazobactam (Na)

Tazobactam (Na) is a triazolylmethyl penicillanic acid sulphone. Tazobactam (Na) is a potent inhibitor of many β lactamase. Tazobactam (Na) is given in combination of piperacillin antibiotic, it enhances and extends the antibiotic spectrum of piperacillin to include many β lactamase producing bacteria normally resistant to it and other β lactam antibiotics.

Brands
TAZOCIN TANZO TANZO TAZOBACT TAZOBACT TAZOP TAZOP TAZOMAX TAZOPIP PIP-TAZO PIP-TAZO PIPETAZO MEPNAM
Adult Dose
Dose: 500 mg
Single Dose: 500 (500)
Frequency: 8 hourly
Route: Slow IV
Instructions: In combinaiton with Piperacillin (Na).
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
Tazobactam is the derivative of Tazobactam (Na). It is of Synthetic origin and belongs to Penicillanic acid sulphone. It belongs to Antibacterial pharmacological group.The Molecular Weight of Tazobactam (Na) is 322.30. Its pKa is 2.1.
Contraindications
Tazobactam (Na) is contraindicated in conditions like Hypersensitivity.
Effects
Tazobactam (Na) produces potentially life-threatening effects which include Pseudomembranous colitis, Anaphylaxis. which are responsible for the discontinuation of Tazobactam (Na) therapy.The symptomatic adverse reactions produced by Tazobactam (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Tiredness, Vomiting, Diarrhea, Fever, Dry mouth, Rashes, Erythema, Allergic reactions, Hallucination, Hot flushes, Muscular weakness, GI disturbance, Muscle pain, Reaction at injection site.
Indications
Tazobactam (Na) is primarily indicated in conditions like Intra-abdominal infections, Respiratory tract infections, Septicaemia, Skin infections, Urinary tract infection.
Interactions
No data regarding the interactions of Tazobactam (Na) was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inf Store in refrigerator. Do not Freeze.
Warnings
Tazobactam should be used with caution in patients with pre-existing kidney disease, cystic fibrosis, other illnesses or any allergy especially to penicillin or other antibiotics. It should be used only if clearly needed during pregnancy or lactation.
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