Bromocriptine (Mesylate)

Bromocriptine (Mesylate) is the 2-bromo derivative of a-ergocryptine. Bromocriptine an ergotamine (an alkaloid with vasoconstrictor action), is a dopamine agonist and mimics the action of dopamine. The effects of bromocriptine are similar to those fo Levodopa. The drug produces little effects in patients who do not react to Levodopa. But Bromocriptine (Mesylate) is often used with Levodopa in patients responding to drug therapy.

Brands
CRIPTON CRIPTON BROMICON BROLIB BROMOCRIPTINE PARLODEL BROTIN BROMOTIN
Adult Dose
Dose: 1.25 to 2.5 mg
Single Dose: 1.9 (1.875)
Frequency: 12 hourly
Route: PO
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Ergot. It belongs to D2 agonist pharmacological group on the basis of mechanism of action and also classified in Antiparkinson Agents pharmacological group.The Molecular Weight of Bromocriptine (Mesylate) is 750.80. Its pKa is 4.9.
Contraindications
Bromocriptine (Mesylate) is contraindicated in conditions like Hypertension in pregnancy,Toxaemia of pregnancy,Neurological disorders,Breast disease,Hypersensitivity to the drug.
Effects
The severe or irreversible adverse effects of Bromocriptine (Mesylate), which give rise to further complications include Pleural effusion, Parkinsonism.The signs and symptoms that are produced after the acute overdosage of Bromocriptine (Mesylate) include Nausea, Vomiting, Drowsiness, Hallucinations, Postural hypotension, Dizziness, Sweating.The symptomatic adverse reactions produced by Bromocriptine (Mesylate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Fatigue, Nausea, Vomiting, Confusion, Hallucination, Postural hypotension.
Indications
'Bromocriptine (Mesylate) is primarily indicated in conditions like Acromegaly, Anovulatory infertility, Cyclical benign breast disease, Galactorrhoea, Hyperprolactinaemia, Hypogonadism, Infertility, Infertility without hyperprolactinaemia, Parkinsonism, Parkinson''s disease, Premenstrual syndrome, Premenstural syndrome, Prolactinoma, Suppression of lactation, and can also be given in adjunctive therapy as an alternative drug of choice in Lactation.'
Interactions
Bromocriptine (Mesylate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholTolerance of Bromocriptine reduced by Alcohol.Cyclosporin ADomperidoneHypoprolactenamic effect of bromocriptine possibly antagonized by Domperidone. DomperidoneHyperprolactanemia effect of Bromocriptine possibly antagonized by Domperidone.ErythromycinPlasma concentration of Bromocriptine increased by Erythromycin (increased risk of toxicity). ErythromycinErythromycin reduces the hepatic metabolism of bromocriptine results in icreased plasma level of bromocriptine leads to toxicityModerateClosely monitor for signs of toxicity. Reduce the doseof bromocriptine.GriseofulvinMetoclopramide (HCl)Hypoprolactenamic effect of bromocriptine possibly antagonized by Metoclopramide.Octreotide (Acetate)Plasma concentration of Bromocriptine increased by Octreotide.Phenylpropanolamine (HCl)Risk of toxicity when Bromocriptine given wih Phenylpropanolamine.MajorProtirelinTamoxifen (Citrate)VORICONAZOLEVoriconazole may increase the serum concentration of bromocriptine likely by decreasing its metabolism. Concomitant therapy is contraindicated. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Caps Store in a well closed container, at room temperature, Below 25°C. Protect from Sunlight and Moisture.
Warnings
Bromocriptine should be used with caution in patients with history of heart attack, angina (heart pain), liver disease, kidney disease, psychiatric illness or circulation problems in the fingers in cold weather. This medication should be used only when clearly needed during pregnancy. This drug is not recommended during lactation.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.