Bretylium (Tosylate)

Bretylium (Tosylate) is a potassium channel blocking agent. Bretylium (Tosylate) is a quaternary salt and is an adrenergic neurona blocking agent. It was first introduced as an antihypertensive agent.Bretylium (Tosylate) is now used as an antiarrhythmic agent. It interferes with the neuronal release of catecholamines but also has direct antiarrhythmic properties.

Brands
Adult Dose
Dose: 5 to 10 mg/kg
Single Dose: 7.5 (7.5)
Frequency: As recommended.
Route: IM
Instructions: Maintenance, Every 6-8 Hours, As Required
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Toluene sulphonate. It belongs to Adrenergic Neurone Blockade pharmacological group on the basis of mechanism of action and also classified in Anti arrhythmic agents pharmacological group.The Molecular Weight of Bretylium (Tosylate) is 414.40. Its pKa is not relevant.
Contraindications
Bretylium (Tosylate) is contraindicated in conditions like Cardiac arrhythmia,Myocardial infarction,Digitalis induced arrythmias.
Effects
Bretylium (Tosylate) produces potentially life-threatening effects which include Hypotension. which are responsible for the discontinuation of Bretylium (Tosylate) therapy.The signs and symptoms that are produced after the acute overdosage of Bretylium (Tosylate) include Severe hypotension.The symptomatic adverse reactions produced by Bretylium (Tosylate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Facial flushing, Transient increase in blood pressure, Parotid pain and swelling, Transient diplopia, Nausea and vomiting.
Indications
Bretylium (Tosylate) is primarily indicated in conditions like Prophylaxis of acid aspiration in obstetrics, Ventricular arrhythmias.
Interactions
Bretylium (Tosylate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmitriptyline (HCl)ArtemisininImipramine (HCl)IsoproterenolBretylium may increase effects of Isoproterenol. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store at room temperature. Do not Freeze.
Warnings
Increase dose interval of bretylium in renal dysfunction. Dilute for IV use except in treating existing ventricular fibrillation where it should be given as rapidly as possible.
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