Somatostatin

Somatostatin is a growth hormone-inhibiting hormone. Somatostatin is used in the treatment of acromegaly due to hormone secreting tumors.


Adult Dose
Dose: 3 ug/ kg/hr
Single Dose: 3 (3)
Frequency: 12 hourly
Route: IV Inf
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
belongs to Tetradecapeptide. It belongs to Hematological Agents and Acute Variceal Bleeding pharmacological group.The Molecular Weight of Somatostatin is 1637.90.
Contraindications
Somatostatin is contraindicated in conditions like Pregnancy,Lactation,Hypersensitivity to any component of product.
Effects
The severe or irreversible adverse effects of Somatostatin, which give rise to further complications include Thrombocytopenia, Extra systoles.The signs and symptoms that are produced after the acute overdosage of Somatostatin include Transient bradycardia, Cramping.The symptomatic adverse reactions produced by Somatostatin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea and vomiting, Pyrexia, Hypoglycemia, Hypocalcemia.
Indications
Somatostatin is primarily indicated in conditions like Adjunct in ganciclovir treatment, Oesophageal varices bleeding.
Interactions
Somatostatin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementHexobarbitone (Na)Somatostatin has been demonstrated to prolong or enhance the effects of Hexobarbitone (Na).InsulinThe glucoregulatory properties of somatostatin may cause it to interfere with the insulin requirements of insulin-dependent diabeticsTechnetium Tc-99m DisofeninSomatostatin may decrease gallbladder emptying thus delaying gallbladder clearance of technetium Tc 99m disofenin.Technetium Tc-99m lidofeninSomatostatin may decrease gallbladder emptying, thus delaying gallbladder clearance of technetium Tc 99m lidofenin. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
IV Inf Store in a well closed container. Refrigeration is recommended. Protect from Sunlight.
Warnings
Blood sugar should be monitored since somatotropin may interfere with carbohydrate metabolism. Concomitant parental nutrition has been suggested because of the inhibitory effect on intestinal absorption.
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