Bovine Insulin

Insulin is a hormone produced by the beta cells of the islets of langerhans of the pancres and consists of 2 chains of aminoacids. It contains 51 amino acid arranged in two chains (A and B) joined together by disulfide linkage. In 1921, Banting and Best extracted insulin from the pancrease and demonstrated its therapeutic effects in diabetic dogs and human subjects.

Brands
INSULIN LENTE INSULIN NPH INSULIN REGULAR INSULIN REGULAR (BOVINE) INSULIN NPH (BOVINE) INSULIN
Adult Dose
Dose: 0.1 to 0.4 IU/ kg
Single Dose: 0.25 (0.25)
Frequency: 24 hourly
Route: IV
Instructions:
Neonatal
Paedriatic
Characteristics
. It is of Natural origin and belongs to Polypeptide. It belongs to Insulin agonist pharmacological group on the basis of mechanism of action and also classified in Antidiabetic Agent, Insulin pharmacological group.The Molecular Weight of Bovine Insulin is 5734.00. Its pKa is Amphoteric.
Contraindications
Bovine Insulin is contraindicated in conditions like Hypersensitivity.
Effects
Bovine Insulin produces potentially life-threatening effects which include Hypoglycemia. which are responsible for the discontinuation of Bovine Insulin therapy.The symptomatic adverse reactions produced by Bovine Insulin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Allergy, Lipoatrophy, Antibody formation.
Indications
Bovine Insulin is primarily indicated in conditions like Diabetes mellitus, Hyperkalaemia.
Interactions
Bovine Insulin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineAlcoholCaptoprilACE inhibitors (e.g Captopril) possibly enhance hypoglycemic effect of insulin. Chlorpromazine (HCl)Clonidine (HCl)CyclophosphamideDanazolIsoniazid These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
IM Inj, SC Inj, IV Inf Store at room temperature or refrigerator. Do not Freeze. Protect from Sunlight. Use within 2 yrs (at4C) if refrigerated and within 1 month if kept at room temperature. Powder Store in a well closed container. Freezing is recommended. Protect from Sunlight.
Warnings
It should be used with caution in case of bovine hypersensitivity, breast feeding, coma, diarrhea, fever, infections, porcine hypersensitivity, renal inpairment, surgery, thyroid disease, trauma, and vomiting.
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