Roxithromycin

Roxithromycin is a macrolide with antibacterial properties similar to that of Erythromycin. Roxithromycin is active against gram positive bacteria for example, staphylococci, streptococci, listeria, corynebacteria; gram negative bacteria for example gonococci, Hemophilus influenza, Hemophilus ducreyi, Legionella, and atypical pathogen, for example mycoplasma and chlamydia. Roxithromycin is well torelated by children and adults. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular interval of time throughout the day and night as prescribed. Roxithromycin is important to take the drug for the full time period as prescribed, discontinuation of the drug may result in ineffective treatment.


Adult Dose
Dose: 150 mg
Single Dose: 150 (150)
Frequency: 12 hourly
Route: PO
Instructions: Take before meal.
Neonatal
Paedriatic
Characteristics
. It is of Semi Synthetic origin and belongs to Methyloxime. It belongs to Macrolide pharmacological group.The Molecular Weight of Roxithromycin is 837.00.
Contraindications
Roxithromycin is contraindicated in conditions like Hepatic disease,Hypersensitivity.
Effects
The symptomatic adverse reactions produced by Roxithromycin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Headache, Diarrhea, Rashes, Nausea and vomiting, Elevated alkaline phosphatase, Epigastric pain, GI disturbance, Elevated SGPT & SGOT.
Indications
Roxithromycin is primarily indicated in conditions like Ent infections, Genitourinary tract infections, Pneumonia, Skin infections.
Interactions
Roxithromycin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAstemizoleCimetidine (HCl)DigoxinTerfenadine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Protect from Sunlight.
Warnings
Precaution should be taken in hepatic insufficiency, prenancy and lactation. It should be used with caution in patients with any allergy, especially to antibiotics. Take appropriate measures if secondary infection occurs.
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